Rule 424(b)(2) Prospectus Supplement
                                            Registration No. 333-48800


PROSPECTUS SUPPLEMENT NO. 1
TO PROSPECTUS DATED August 16, 2001


                                 180,995 Shares

                          BioMarin Pharmaceutical Inc.

                                  Common Stock



     This  Prospectus  Supplement  supplements  information  contained  in  that
certain  Prospectus  of  BioMarin  Pharmaceutical  Inc.  dated  August 16,  2001
relating to the potential sale and issuance from time to time of up to 2,500,000
shares of BioMarin  common  stock.  This  Prospectus  Supplement is not complete
without,  and may not be delivered or utilized  except in connection  with,  the
Prospectus,  including any amendments or supplements  thereto.  This  Prospectus
Supplement is  incorporated  by reference into the  Prospectus.  You should read
this Prospectus Supplement and the accompanying  Prospectus carefully before you
invest.  Both documents contain information you should consider carefully before
making your investment decision.

     See "Risk  Factors"  beginning  on page 5 of the  Prospectus  to read about
risks that you should consider before buying shares of our common stock.


     You  should  rely  only on the  information  provided  or  incorporated  by
reference  in this  Prospectus  Supplement  and  the  Prospectus.  We  have  not
authorized anyone else to provide you with different information. You should not
assume that the information in this Prospectus  Supplement is accurate as of any
date other than the date on the front of this Prospectus Supplement.


     NEITHER  THE  SECURITIES  EXCHANGE  COMMISSION  NOR  ANY  STATE  SECURITIES
COMMISSION  HAS APPROVED OR  DISAPPROVED  OF THE  SECURITIES  OR PASSED UPON THE
ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY REPRESENTATION TO THE CONTRARY IS A
CRIMINAL OFFENSE.


            The date of this Prospectus Supplement is August 23, 2001














































                                TABLE OF CONTENTS


                              PROSPECTUS SUPPLEMENT

Plan of Distribution........................................................S-1



                                   PROSPECTUS

Summary.......................................................................1

The Offering..................................................................3

Forward Looking Statements....................................................4

Risk Factors..................................................................5

Use of Proceeds..............................................................16

Plan of Distribution.........................................................17

Legal Matters................................................................19

Experts......................................................................19



     The following  information  supplements  the  information  set forth in the
Prospectus.


                              PLAN OF DISTRIBUTION



     On August 23,  2001,  we will issue and sell  180,995  shares of our common
stock to Acqua  Wellington North American  Equities Fund, Ltd.  pursuant to this
prospectus  supplement  and pursuant to the terms of the common  stock  purchase
agreement  entered into between Acqua  Wellington and us on August 15, 2001. The
common stock will be purchased at a negotiated purchase price of $11.05. We will
pay Reedland  Capital  Partners,  an  Institutional  Division of Financial  West
Group, a fee of $20,000 in  consideration of placement agent services related to
this purchase by Acqua  Wellington.  We will not pay any other  compensation  in
conjunction  with the sale of these  shares of our  common  stock.  See "Plan of
Distribution" beginning on page 17 of the prospectus.





































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