UNITED
STATES
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SECURITIES
AND EXCHANGE COMMISSION
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Washington,
D.C. 20549
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SCHEDULE
13G
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(Rule
13d-102)
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Information
Statement Pursuant to Rules 13d-1 and 13d-2
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Under
the Securities Exchange Act of 1934
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(Amendment
No. )*
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Altus
Pharmaceuticals Inc.
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(Name
of Issuer)
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Common
Stock
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(Title
of Class of Securities)
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02216N105
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(CUSIP
Number)
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February
6, 2008
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Date
of Event Which Requires Filing of the
Statement
|
CUSIP
NO.
02216N105
|
13G
|
Page 2
of 10
Pages
|
1.
|
NAME
OF REPORTING PERSON
S.S.
OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Citadel
Investment Group, L.L.C.
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||
2.
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) x
(b) o
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3.
|
SEC
USE ONLY
|
||
4.
|
CITIZENSHIP
OR PLACE OF ORGANIZATION
Delaware
limited liability company
|
||
NUMBER
OF
SHARES
BENEFICIALLY
OWNED
BY
EACH
REPORTING
PERSON
WITH
|
5.
|
SOLE
VOTING POWER
0
|
|
6.
|
SHARED
VOTING POWER
1,663,173
shares
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||
7.
|
SOLE
DISPOSITIVE POWER
0
|
||
8.
|
SHARED
DISPOSITIVE POWER
See
Row 6 above.
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||
9.
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
See
Row 6 above.
|
||
10.
|
CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
CERTAIN
SHARES o
|
||
11.
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
Approximately
5.4%(1)
as of the date of this filing
|
||
12.
|
TYPE
OF REPORTING PERSON
OO;
HC
|
CUSIP
NO.
02216N105
|
13G
|
Page
3 of 10
Pages
|
1.
|
NAME
OF REPORTING PERSON
S.S.
OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Citadel
Limited Partnership
|
||
2.
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) x
(b) o
|
||
3.
|
SEC
USE ONLY
|
||
4.
|
CITIZENSHIP
OR PLACE OF ORGANIZATION
Delaware
limited liability company
|
||
NUMBER
OF
SHARES
BENEFICIALLY
OWNED
BY
EACH
REPORTING
PERSON
WITH
|
5.
|
SOLE
VOTING POWER
0
|
|
6.
|
SHARED
VOTING POWER
1,663,173
shares
|
||
7.
|
SOLE
DISPOSITIVE POWER
0
|
||
8.
|
SHARED
DISPOSITIVE POWER
See
Row 6 above.
|
||
9.
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
See
Row 6 above.
|
||
10.
|
CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
|
||
11.
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
Approximately
5.4%(2)
as of the date of this filing
|
||
12.
|
TYPE
OF REPORTING PERSON
PN;
HC
|
CUSIP
NO.
02216N105
|
13G
|
Page 4
of 10
Pages
|
1.
|
NAME
OF REPORTING PERSON
S.S.
OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Kennith
Griffin
|
||
2.
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) x
(b) o
|
||
3.
|
SEC
USE ONLY
|
||
4.
|
CITIZENSHIP
OR PLACE OF ORGANIZATION
U.S.
Citizen
|
||
NUMBER
OF
SHARES
BENEFICIALLY
OWNED
BY
EACH
REPORTING
PERSON
WITH
|
5.
|
SOLE
VOTING POWER
0
|
|
6.
|
SHARED
VOTING POWER
1,663,173
shares
|
||
7.
|
SOLE
DISPOSITIVE POWER
0
|
||
8.
|
SHARED
DISPOSITIVE POWER
See
Row 6 above.
|
||
9.
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
See
Row 6 above.
|
||
10.
|
CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
|
||
11.
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
Approximately
5.4%(3)
as of the date of this filing
|
||
12.
|
TYPE
OF REPORTING PERSON
IN;
HC
|
CUSIP
NO.
02216N105
|
13G
|
Page 5
of 10
Pages
|
1.
|
NAME
OF REPORTING PERSON
S.S.
OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
Citadel
Equity Fund Ltd.
|
||
2.
|
CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP
(a) x
(b) o
|
||
3.
|
SEC
USE ONLY
|
||
4.
|
CITIZENSHIP
OR PLACE OF ORGANIZATION
Cayman
Islands company
|
||
NUMBER
OF
SHARES
BENEFICIALLY
OWNED
BY
EACH
REPORTING
PERSON
WITH
|
5.
|
SOLE
VOTING POWER
0
|
|
6.
|
SHARED
VOTING POWER
1,663,173
shares
|
||
7.
|
SOLE
DISPOSITIVE POWER
0
|
||
8.
|
SHARED
DISPOSITIVE POWER
See
Row 6 above.
|
||
9.
|
AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
See
Row 6 above.
|
||
10.
|
CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
CERTAIN
SHARES o
|
||
11.
|
PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
Approximately
5.4%(4)
as of the date of this filing
|
||
12.
|
TYPE
OF REPORTING PERSON
CO
|
CUSIP
NO.
02216N105
|
13G
|
Page 6
of 10
Pages
|
Item
1(a)
|
Name
of Issuer: Altus
Pharmaceuticals Inc.
|
Item
2(a)
|
Name
of Person Filing(5)
|
Item
2(b)
|
Address
of Principal Business Office
|
Item
2(c)
|
Citizenship
|
Citadel
Investment Group, L.L.C.
|
131
S. Dearborn Street
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32nd
Floor
|
Chicago,
Illinois 60603
|
Delaware
limited liability company
|
Citadel
Limited Partnership
|
131
S. Dearborn Street
|
32nd
Floor
|
Chicago,
Illinois 60603
|
Delaware
limited partnership
|
Kenneth
Griffin
|
131
S. Dearborn Street
|
32nd
Floor
|
Chicago,
Illinois 60603
|
U.S.
Citizen
|
Citadel
Equity Fund Ltd.
|
c/o
Citadel Investment Group, L.L.C.
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131
S. Dearborn Street
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32nd
Floor
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Chicago,
Illinois 60603
|
Cayman
Islands company
|
CUSIP
NO.
02216N105
|
13G
|
Page 7
of 10
Pages
|
Item
3
|
If
this statement is filed pursuant to Rules 13d-1(b), or 13d-2(b)
or (c),
check whether the person filing is
a:
|
(a)
|
[__]
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Broker
or dealer registered under Section 15 of the Exchange
Act;
|
(b)
|
[__]
|
Bank
as defined in Section 3(a)(6) of the Exchange
Act;
|
(c)
|
[__]
|
Insurance
company as defined in Section 3(a)(19) of the Exchange
Act;
|
CUSIP
NO.
02216N105
|
13G
|
Page 8
of 10
Pages
|
(d)
|
[__]
|
Investment
company registered under Section 8 of the Investment Company
Act;
|
(e)
|
[__]
|
An
investment adviser in accordance with Rule
13d-1(b)(1)(ii)(E);
|
(f)
|
[__]
|
An
employee benefit plan or endowment fund in accordance with Rule
13d-1(b)(1)(ii)(F);
|
(g)
|
[__]
|
A
parent holding company or control person in accordance with Rule
13d-1(b)(1)(ii)(G);
|
(h)
|
[__]
|
A
savings association as defined in Section 3(b) of the Federal Deposit
Insurance Act;
|
(i)
|
[__]
|
A
church plan that is excluded from the definition of an investment
company
under Section 3(c)(14) of the Investment Company
Act;
|
(j)
|
[__]
|
Group,
in accordance with Rule
13d-1(b)(1)(ii)(J).
|
Item
4
|
Ownership:
|
(a)
|
Amount
beneficially owned:
|
(c)
|
Number
of shares as to which such person
has:
|
(i)
|
sole
power to vote or to direct the
vote:
|
0
|
CUSIP
NO.
02216N105
|
13G
|
Page 9
of 10
Pages
|
(ii)
|
shared
power to vote or to direct the
vote:
|
(iii)
|
sole
power to dispose or to direct the disposition
of:
|
0
|
(iv)
|
shared
power to dispose or to direct the disposition
of:
|
Item
5
|
Ownership
of Five Percent or Less of a Class:
|
Item
6
|
Ownership
of More than Five Percent on Behalf of Another
Person:
|
Item
7
|
Identification
and Classification of the Subsidiary which Acquired the Security
Being
Reported on by the Parent Holding
Company:
|
Item
8
|
Identification
and Classification of Members of the
Group:
|
Item
9
|
Notice
of Dissolution of Group:
|
(6)
|
See
footnote 1 above.
|
Item
10
|
Certification:
|
CUSIP
NO.
02216N105
|
13G
|
Page 10
of 10
Pages
|
KENNETH
GRIFFIN
By: /s/
John C. Nagel
John
C. Nagel, attorney-in-fact*
CITADEL
LIMITED PARTNERSHIP
By: Citadel
Investment Group, L.L.C.,
its
General Partner
By: /s/
John C. Nagel
John
C. Nagel, Authorized Signatory
|
CITADEL
EQUITY FUND LTD.
By: Citadel
Limited Partnership,
its
Portfolio Manager
By: Citadel
Investment Group, L.L.C.,
its
General Partner
By: /s/
John C. Nagel
John
C. Nagel, Authorized Signatory
CITADEL
INVESTMENT GROUP, L.L.C.
By: /s/
John C. Nagel
John
C. Nagel, Authorized Signatory
|