FORM 6-K SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 of the Securities Exchange Act of 1934 April 21, 2008 Commission File Number 001-14978 SMITH & NEPHEW plc (Registrant's name) 15 Adam Street London, England WC2N 6LA (Address of registrant's principal executive offices) [Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.] Form 20-F X Form 40-F --- --- [Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1).] Yes No X --- --- [Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7).] Yes No X --- --- [Indicate by check mark whether by furnishing the information contained in this Form, the registrant is also thereby furnishing information to the Commission pursuant to Rule 12g3-2 (b) under the Securities Exchange Act of 1934.] Yes No X --- --- If "Yes" is marked, indicate below the file number assigned to the registrant in connection with Rule 12g3-2 (b) : 82- n/a. SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized. Smith & Nephew plc (Registrant) Date: April 21, 2008 By: /s/ Paul Chambers ----------------- Paul Chambers Company Secretary NOTIFICATION OF MAJOR INTERESTS IN SHARES 1. Name of company Smith & Nephew plc 2. Name of shareholder having a major interest Capital Research and Management Company 3. Please state whether notification indicates that it is in respect of holding of the shareholder named in 2 above or in respect of a non-beneficial interest or in the case of an individual holder if it is a holding of that person's spouse or children under the age of 18 Non-beneficial 4. Name of the registered holder(s) and, if more than one holder, the number of shares held by each of them ................................................................ 5. Number of shares / amount of stock acquired ................................................................ 6. Percentage of issued class ................................................................ 7. Number of shares / amount of stock disposed 2,043,259 8. Percentage of issued class Less than 0.3%............................................................... 9. Class of security Ordinary shares of US 20 cents 10. Date of transaction 17.04.2008 11. Date company informed 18.04.2008 12. Total holding following this notification 43,658,771 13. Total percentage holding of issued class following this notification 4.9048% 14. Any additional information ................................................................ 15. Name of contact and telephone number for queries Gemma Parsons - Assistant Company Secretary 020 7960 2228 16. Name and signature of authorised company official responsible for making this notification Gemma Parsons - Assistant Company Secretary Date of notification 21.04.08 The FSA does not give any express or implied warranty as to the accuracy of this document or material and does not accept any liability for error or omission. The FSA is not liable for any damages (including, without limitation, damages for loss of business or loss of profits) arising in contract, tort or otherwise from the use of or inability to use this document, or any material contained in it, or from any action or decision taken as a result of using this document or any such material.