Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Macaluso Peter M
 2. Date of Event Requiring Statement (Month/Day/Year)
02/01/2013		 3. Issuer Name and Ticker or Trading Symbol
AMICUS THERAPEUTICS INC [FOLD]
(Last)
(First)
(Middle)
1 CEDAR BROOK DRIVE		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
VP & Corporate Counsel
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

CRANBURY, NJ 08512		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Options (right to buy) 08/01/2012 08/06/2018 Common Stock 10,000 $ 16.71 D  
Stock Options (right to buy) 02/01/2013 02/03/2019 Common Stock 7,000 $ 10.36 D  
Stock Options (right to buy)   (1) 11/16/2019 Common Stock 15,000 $ 4.16 D  
Stock Options (right to buy)   (2) 03/16/2020 Common Stock 10,000 $ 3.32 D  
Stock Options (right to buy)   (3) 06/15/2020 Common Stock 10,000 $ 2.81 D  
Stock Options (right to buy)   (4) 01/19/2021 Common Stock 12,500 $ 5.96 D  
Stock Options (right to buy)   (5) 06/16/2021 Common Stock 17,500 $ 6.06 D  
Stock Options (right to buy)   (6) 02/15/2022 Common Stock 12,500 $ 6.45 D  
Stock Options (right to buy)   (6) 06/04/2022 Common Stock 12,500 $ 4.38 D  
Stock Options (right to buy)   (7) 01/28/2023 Common Stock 35,000 $ 3.53 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Macaluso Peter M
1 CEDAR BROOK DRIVE
CRANBURY, NJ 08512		       VP & Corporate Counsel  

Signatures

/s/ Peter M. Macaluso 02/11/2013
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, vested on November 16, 2010. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments, beginning on December 1, 2010, with the final installment vesting on November 1, 2013.
(2) These options vest and become exercisable in a series of installments. The first installment, which consisted of 25% of the total aggregate number of options granted, vested on March 16, 2011. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments, beginning on April 1, 2011, with the final installment vesting on March 1, 2014.
(3) These options vest and become exercisable in a series of installments. The first installment, which consisted of 25% of the total aggregate number of options granted, vested on June 15, 2011. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments, beginning on July 1, 2011, with the final installment vesting on June 1, 2014.
(4) These options vest and become exercisable in a series of installments. The first installment, which consisted of 25% of the total aggregate number of options granted, vested on January 19, 2012. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments, beginning on February 1, 2012, with the final installment vesting on January 1, 2015.
(5) These options vest and become exercisable in a series of installments. The first installment, which consisted of 25% of the total aggregate number of options granted, vested on June 16, 2012. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments, beginning on July 1, 2012, with the final installment vesting on June 1, 2015.
(6) These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, vests on February 15, 2013. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments, beginning on March 1, 2013, with the final installment vesting on February 1, 2016.
(7) These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, vests on January 28, 2014. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments, beginning on February 1, 2014, with the final installment vesting on January 1, 2017.

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