UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                             ----------------------

                                    FORM 8-K

                                 CURRENT REPORT

                     PURSUANT TO SECTION 13 OR 15(d) OF THE
                         SECURITIES EXCHANGE ACT OF 1934

                              --------------------

          Date of report (Date of earliest event reported): May 1, 2006

                            Applied DNA Sciences, Inc
               (Exact Name of Registrant as Specified in Charter)


           Nevada                   002-90539                  59-2262718
      (State or Other        (Commission File Number)        (IRS Employer
       Jurisdiction                                       Identification No.)
     of Incorporation)


                       25 Health Sciences Drive, Suite 113
                           Stony Brook, New York 11790
               (Address of Principal Executive Offices) (Zip Code)

                                  631-444-6861
              (Registrant's telephone number, including area code)

                                 Not Applicable
          (Former Name or Former Address, if Changed Since Last Report)


Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2 below):

|_|   Written communications pursuant to Rule 425 under the Securities Act
      (17 CFR 230.425)

|_|   Soliciting  material  pursuant to Rule 14a-12 under the Exchange Act
      (17 CFR 240.14a-12)

|_|   Pre-commencement  communications  pursuant  to  Rule  14d-2(b)  under  the
      Exchange Act (17 CFR 240.14d-2(b))

|_|   Pre-commencement  communications  pursuant  to  Rule  13e-4(c)  under  the
      Exchange Act (17 CFR 240.13e-4(c))





Item 1.01 Entry into a Material Definitive Agreement.
Item 2.03 Creation of a Direct Financial Obligation.
Item 3.02 Unregistered Sales of Equity Securities.

      On May 2, 2006,  Applied DNA  Sciences,  Inc., a Nevada  corporation  (the
"Company"), completed the first tranche of a private placement (the "Placement")
of up to 140 units at $50,000 per unit for sale to  "accredited  investors"  who
are not a "U.S. person," as each is defined in regulations promulgated under the
Securities  Act. In this first tranche,  the Company sold 20 units for aggregate
gross proceeds of $1,000,000. Each such unit consists of (i) a $50,000 Principal
Amount 10% Secured  Convertible  Promissory  Note and (ii) a warrant to purchase
100,000 shares of the Company's  common stock  exercisable  for a period of four
years  commencing  on May 2,  2007,  at a price of $0.50  per  share.  Each such
warrant may be redeemed  at the option of the Company at a  redemption  price of
$0.001  upon the  earlier of (i) May 2, 2009,  and (ii) the date a  registration
statement  for the  resale of the  underlying  common  stock  has been  declared
effective by the Securities and Exchange Commission (the "Commission"),  and the
Company's  stock has traded on The Over the Counter  Bulletin  Board at or above
$1.00  per share for 20  consecutive  trading  days.  The  promissory  notes and
accrued but unpaid interest  thereon are convertible into shares of common stock
of the  Company  at a price of $0.50 per share by the  holder of the  promissory
notes at any time from May 2, 2006, through May 2, 2007, and shall automatically
convert on such date at a 20%  discount to the average of the closing bid prices
of the Company's common stock on trading days during the 12 months prior to such
conversion.  The promissory notes bear interest at the rate of 10% per annum and
are due and  payable  in full on August 2,  2007.  Any  principal  payment of or
interest payment on the outstanding  promissory notes not paid when due, whether
upon maturity,  acceleration or otherwise,  shall bear interest at the lesser of
12% or the maximum rate permissible by law. At any time prior to conversion, the
Company  will have the right to prepay  the  promissory  notes and  accrued  but
unpaid interest thereon upon 3 days notice,  allowing the holders to convert the
promissory notes during such notice period.

      Until the principal and interest  under the  promissory  notes are paid in
full, or converted into common stock of the Company,  the promissory  notes will
be secured  by a security  interest  in all of the assets of the  Company.  This
security  interest will be pari passu with the security  interest granted to the
holders of  $1,500,000  of $50,000  principal  amount  10%  secured  convertible
promissory notes issued as part of a private  placement of the Company completed
on March 8, 2006.  The Company may issue up to $4,500,000 of debt in addition to
the remaining  $6,000,000  that may be sold in the Placement that may be secured
by a security interest in all of the Company's  assets,  which interest would be
pari passu to the  security  interest  granted to the holders of the  promissory
notes and the promissory notes issued in March.

      In connection  with the  Placement,  each  purchaser of a unit has entered
into a  subscription  agreement and a  registration  rights  agreement  with the
Company. Pursuant to this registration right agreement, the Company will prepare
and file a  registration  statement  with the  Commission  for the resale of the
common stock  underlying the promissory notes and the warrants within 30 days of
the  Company's  registration  statement  on Form SB-2,  as amended (SEC File No.
333-122848),  being  declared  effective  by the  Commission,  and  to  use  the
Company's  reasonable  best efforts to have the  registration  statement for the
resale of the common  stock  underlying  the  promissory  notes and the warrants
declared effective by the Commission by no later than 180 days after filing. The
obligations of the Company to file and have such registration statement declared
effective  shall terminate as to any holder of the units upon the earlier of the
date: (a) when all of such holder's common stock underlying the promissory notes
and the  warrants  may be sold during a single three (3) month period under Rule
144 of the  Securities  Act;  and (b) when  all of such  holder's  common  stock
underlying the promissory  notes and the warrants may be transferred  under Rule
144(k) of the Securities  Act,  unless such holder later becomes an affiliate of
the  Company (as  defined in Rule 144 of the  Securities  Act) in which case the
Company's  obligation  shall be revived  until such  holder's  rights  otherwise
terminate under clause (a) above.





      Arjent Limited served as the Company's  placement  agent in the Placement.
The Company has agreed to pay from the proceeds of the Placement:  (1) to Arjent
Limited:  (a) a commission  equal to 10% of the gross proceeds of the Placement;
(b) a  non-accountable  expense  allowance equal to 3% and  non-accountable  due
diligence  expenses  equal to 2%, of the gross  proceeds of the  Placement;  (c)
2,400,000  shares of common  stock of the  Company;  and (d)  $75,000 for Arjent
Limited's legal fees and expenses;  and (2) $150,000 to VC Arjent Ltd., formerly
known as Vertical Capital Partners, Inc., for consulting and management fees.

      The Company claims an exemption from the registration  requirements of the
Securities  Act for the private  placement of the units pursuant to Regulation S
promulgated  under the  Securities Act because each of the units were sold in an
"offshore  transaction" to persons who are not a "U.S.  person," in each case as
defined in Regulation S.

Item 8.01 Other Events.

      On May 1, 2006,  the Company issued a press release to announce the launch
of its  SigNature  Botanical  DNA  Authentication  Program.  A copy of the press
release is attached as Exhibit 99.1 to this Current Report on Form 8-K.

Item 9.01 Financial Statements and Exhibits

      (d)   Exhibits.

      Exhibit 10.1  Form of  Subscription  Agreement by and between  Applied DNA
                    Sciences, Inc. and each purchaser of a unit.

      Exhibit 10.2  Form of 10% Secured  Convertible  Promissory Note of Applied
                    DNA Sciences, Inc.

      Exhibit 10.3  Form of Warrant Agreement of Applied DNA Sciences, Inc.

      Exhibit 10.4  Form of  Registration  Rights  Agreement  by and between the
                    Applied DNA Sciences, Inc. and each purchaser of a unit.

      Exhibit 99.1  Press  release of Applied DNA Sciences,  Inc.,  dated May 1,
                    2006.






                                    SIGNATURE

      Pursuant to the  requirements of the Securities  Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

                                       Applied DNA Sciences, Inc.
                                       (Registrant)



                                       By: /s/ James  Hayward
                                       --------------------------------------
                                       James Hayward
                                       Chief Executive Officer




Date: May 5, 2006





Exhibit No.    Description of Exhibit
-----------    ----------------------

10.1           Form  of  Subscription  Agreement  by  and  between  Applied  DNA
               Sciences, Inc. and each purchaser of a unit.

10.2           Form of 10% Secured  Convertible  Promissory  Note of Applied DNA
               Sciences, Inc.

10.3           Form of Warrant Agreement of Applied DNA Sciences, Inc.

10.4           Form of Registration  Rights Agreement by and between the Applied
               DNA Sciences, Inc. and each purchaser of a unit.

99.1           Press Release of Applied DNA Sciences, Inc., dated May 1, 2006.