SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, DC  20549

                                  SCHEDULE 13G
                                 (Rule 13d-102)

            INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
          TO RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED
                              PURSUANT TO 13d-2(b)



                          BIOMARIN PHARMACEUTICAL INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)


                                  COMMON STOCK
--------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                  09061G 10 1
--------------------------------------------------------------------------------
                                 (CUSIP Number)


                               December 31, 2000
--------------------------------------------------------------------------------
            (Date of Event which Requires Filing of this Statement)



Check the appropriate box to designate the one pursuant to which this Schedule
is filed:

        [ ]  Rule 13d-1(b)

        [ ]  Rule 13d-1(c)

        [X]  Rule 13d-1(d)



/1/ The remainder of this cover page shall be filled out for a reporting
person's initial filing on this with respect to the subject class of securities,
and for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 (the "Act") or otherwise subject to the liabilities of that section of the
Act but shall be subject to all other provisions of the Act (however, see the
Notes).


  CUSIP NO. 09061G 10 1                    13G          Page 2 of 17 Pages
           -------------


------------------------------------------------------------------------------
      NAME OF REPORTING PERSON
 1    S. S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


      MPM Capital L.P.
------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
 2                                                              (a) [_]
                                                                (b) [X]

------------------------------------------------------------------------------
      SEC USE ONLY
 3


------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
        Delaware

------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF
                            2,810,787 (1)
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6

     OWNED BY               None
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING              2,810,787 (1)

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                           None
------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
         2,810,787 (1)
------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
10    (SEE INSTRUCTIONS)
                                                                    [_]

------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
11

        7.65%
------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
12

       PN
------------------------------------------------------------------------------
      *SEE INSTRUCTIONS BEFORE FILLING OUT!


  CUSIP NO. 09061G 10 1                    13G          Page 3 of 17 Pages
           -------------


------------------------------------------------------------------------------
      NAME OF REPORTING PERSON
 1    S. S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


      BB BioVentures L.P.
------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
 2                                                              (a) [_]
                                                                (b) [X]

------------------------------------------------------------------------------
      SEC USE ONLY
 3


------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
        Delaware

------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF
                            2,810,787 (1)
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6

     OWNED BY               None
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING              2,810,787 (1)

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                           None
------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
         2,810,787 (1)
------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
10    (SEE INSTRUCTIONS)
                                                                    [_]

------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
11

        7.65%
------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
12

       PN
------------------------------------------------------------------------------
      *SEE INSTRUCTIONS BEFORE FILLING OUT!


  CUSIP NO. 09061G 10 1                    13G          Page 4 of 17 Pages
           -------------


------------------------------------------------------------------------------
      NAME OF REPORTING PERSON
 1    S. S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


      BAB BioVentures, LP
------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
 2                                                              (a) [_]
                                                                (b) [X]

------------------------------------------------------------------------------
      SEC USE ONLY
 3


------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
        Delaware

------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF
                            2,810,787 (1)
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6

     OWNED BY               None
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING              2,810,787 (1)

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                           None
------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
         2,810,787 (1)
------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
10    (SEE INSTRUCTIONS)
                                                                    [_]

------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
11

        7.65%
------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
12

       PN
------------------------------------------------------------------------------
      *SEE INSTRUCTIONS BEFORE FILLING OUT!


  CUSIP NO. 09061G 10 1                    13G          Page 5 of 17 Pages
           -------------


------------------------------------------------------------------------------
      NAME OF REPORTING PERSON
 1    S. S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


      MPM BioVentures Parallel Fund, L.P.
------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
 2                                                              (a) [_]
                                                                (b) [X]

------------------------------------------------------------------------------
      SEC USE ONLY
 3


------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
        Delaware

------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF
                            2,810,787 (1)
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6

     OWNED BY               None
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING              2,810,787 (1)

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                           None
------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
         2,810,787 (1)
------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
10    (SEE INSTRUCTIONS)
                                                                    [_]

------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
11

        7.65%
------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
12

       PN
------------------------------------------------------------------------------
      *SEE INSTRUCTIONS BEFORE FILLING OUT!



  CUSIP NO. 09061G 10 1                    13G          Page 6 of 17 Pages
           -------------


------------------------------------------------------------------------------
      NAME OF REPORTING PERSON
 1    S. S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


      BAB BioVentures, N.V.
------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
 2                                                              (a) [_]
                                                                (b) [X]

------------------------------------------------------------------------------
      SEC USE ONLY
 3


------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
        Netherlands Antilles

------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF
                            2,810,787 (1)
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6

     OWNED BY               None
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING              2,810,787 (1)

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                           None
------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
         2,810,787 (1)
------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
10    (SEE INSTRUCTIONS)
                                                                    [_]

------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
11

        7.65%
------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
12

       CO
------------------------------------------------------------------------------
      *SEE INSTRUCTIONS BEFORE FILLING OUT!


  CUSIP NO. 09061G 10 1                    13G          Page 7 of 17 Pages
           -------------


------------------------------------------------------------------------------
      NAME OF REPORTING PERSON
 1    S. S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


      MPM BioVentures I LP
------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
 2                                                              (a) [_]
                                                                (b) [X]

------------------------------------------------------------------------------
      SEC USE ONLY
 3


------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
        Delaware

------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF
                            2,810,787 (1)
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6

     OWNED BY               None
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING              2,810,787 (1)

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                           None
------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
         2,810,787
------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
10    (SEE INSTRUCTIONS)
                                                                    [_]

------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
11

        7.65%
------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
12

       PN
------------------------------------------------------------------------------
      *SEE INSTRUCTIONS BEFORE FILLING OUT!


  CUSIP NO. 09061G 10 1                    13G          Page 8 of 17 Pages
           -------------


------------------------------------------------------------------------------
      NAME OF REPORTING PERSON
 1    S. S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


      MPM BioVentures I LLC
------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
 2                                                              (a) [_]
                                                                (b) [X]

------------------------------------------------------------------------------
      SEC USE ONLY
 3


------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
        Delaware

------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF
                            2,810,787 (1)
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6

     OWNED BY               None
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING              2,810,787 (1)

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                           None
------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
         2,810,787 (1)
------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
10    (SEE INSTRUCTIONS)
                                                                    [_]

------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
11


------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
12

       OO
------------------------------------------------------------------------------
      *SEE INSTRUCTIONS BEFORE FILLING OUT!


  CUSIP NO. 09061G 10 1                    13G          Page 9 of 17 Pages
           -------------


------------------------------------------------------------------------------
      NAME OF REPORTING PERSON
 1    S. S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


      MPM Asset Management LLC
------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
 2                                                              (a) [_]
                                                                (b) [X]

------------------------------------------------------------------------------
      SEC USE ONLY
 3


------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
        Delaware

------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF
                            2,810,787 (1)
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6

     OWNED BY               None
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING              2,810,787 (1)

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                           None
------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
         2,810,787 (1)
------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
10    (SEE INSTRUCTIONS)
                                                                    [_]

------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
11

        7.65%
------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
12

       OO
------------------------------------------------------------------------------
      *SEE INSTRUCTIONS BEFORE FILLING OUT!


  CUSIP NO. 09061G 10 1                    13G          Page 10 of 17 Pages
           -------------


------------------------------------------------------------------------------
      NAME OF REPORTING PERSON
 1    S. S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


      Medical Portfolio Management, LLC
------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
 2                                                              (a) [_]
                                                                (b) [X]

------------------------------------------------------------------------------
      SEC USE ONLY
 3


------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
        Delaware

------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF
                            2,810,787 (1)
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6

     OWNED BY               None
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING              2,810,787 (1)

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                           None
------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
         2,810,787 (1)
------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
10    (SEE INSTRUCTIONS)
                                                                    [_]

------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
11


------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
12

       OO
------------------------------------------------------------------------------
      *SEE INSTRUCTIONS BEFORE FILLING OUT!


  CUSIP NO. 09061G 10 1                    13G          Page 11 of 17 Pages
           -------------


------------------------------------------------------------------------------
      NAME OF REPORTING PERSON
 1    S. S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON


      MPM Asset Management Investors 1998 LLC
------------------------------------------------------------------------------
      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
 2                                                              (a) [_]
                                                                (b) [X]

------------------------------------------------------------------------------
      SEC USE ONLY
 3


------------------------------------------------------------------------------
      CITIZENSHIP OR PLACE OF ORGANIZATION
 4
        Delaware

------------------------------------------------------------------------------
                          SOLE VOTING POWER
                     5
     NUMBER OF
                            2,810,787 (1)
      SHARES       -----------------------------------------------------------
                          SHARED VOTING POWER
   BENEFICIALLY      6

     OWNED BY               None
                   -----------------------------------------------------------
       EACH               SOLE DISPOSITIVE POWER
                     7
    REPORTING              2,810,787 (1)

      PERSON       -----------------------------------------------------------
                          SHARED DISPOSITIVE POWER
       WITH          8
                           None
------------------------------------------------------------------------------
      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
 9
         2,810,787 (1)
------------------------------------------------------------------------------
      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
10    (SEE INSTRUCTIONS)
                                                                    [_]

------------------------------------------------------------------------------
      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
11

        7.65%
------------------------------------------------------------------------------
      TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
12

       OO
------------------------------------------------------------------------------
      *SEE INSTRUCTIONS BEFORE FILLING OUT!


                           STATEMENT ON SCHEDULE 13G

Item 1(a).  Name of Issuer:
            --------------

            BioMarin Pharmaceutical Inc.

Item 1(b).  Address of Issuer's Principal Executive Offices:
            -----------------------------------------------

            371 Bel Marin Keys Boulevard, Suite 210, Novato, CA 94949

Item 2(a).  Names of Person Filing:
            ----------------------

            MPM Capital L.P.
            BB BioVentures L.P.
            BAB BioVentures L.P.
            MPM BioVentures Parallel Fund, L.P.
            BAB BioVentures, N.V.
            MPM BioVentures I LP
            MPM BioVentures I LLC
            MPM Asset Management LLC
            Medical Portfolio Management, LLC
            MPM Asset Management 1998 LLC

Item 2(b).  Business Mailing Address for the Person Filing:
            ----------------------------------------------

            c/o MPM Capital L.P.
            One Cambridge Center, 9th Floor
            Cambridge, MA 02142

Item 2(c).  Citizenship:
            -----------

            All entities were organized in Delaware, except BAB BioVentures,
            N.V., which was formed under the laws of the Netherlands Antilles.

Item 2(d).  Title of Class of Securities:
            ----------------------------

            Common Stock

Item 2(e).  CUSIP Number:
            ------------

            09061G 10 1

Item 3.     If this statement is filed pursuant to Rules 13d-1(b), or 13d-2(b),
            -------------------------------------------------------------------
            check whether the person filing is a:
            ------------------------------------

            Not Applicable

Item 4.     Ownership:
            ---------

            (a)         Amount Beneficially Owned:

                        2,810,787 (1)

            (b)         Percent of Class Owned:

                        7.65%

            (c)         Number of shares as to which such person has:


            (i)   sole power to vote or to direct the vote:
                        2,810,787 shares of Common Stock (1)

            (ii)  shared power to vote or to direct the vote:
                        None

            (iii) sole power to dispose or to direct the disposition of:
                        2,810,787 shares of Common Stock (1)

            (iv)  shared power to dispose or to direct the disposition of:
                        None

Item 5.  Ownership of Five Percent or Less of a Class:
         --------------------------------------------

          Not Applicable

Item 6.  Ownership of More than Five Percent on Behalf of Another Person:
         ---------------------------------------------------------------

          Various persons have the right to receive or the power to direct the
          receipt of dividends from, or the proceeds from the sale of, the
          shares to which this statement relates.  No one person's interest in
          such shares is more than five percent of the total outstanding stock
          of the Issuer.

Item 7.  Identification and Classification of the Subsidiary Which Acquired the
         ----------------------------------------------------------------------
         Security Being Reported on By the Parent Holding Company:
         --------------------------------------------------------

          Not Applicable

Item 8.  Identification and Classification of Members of the Group:
         ---------------------------------------------------------

          Not Applicable

Item 9.  Notice of Dissolution of Group:
         ------------------------------

          Not Applicable

Item 10. Certification:
         -------------

          Not Applicable

(1)  Includes shares held through interests in MPM Capital L.P. ("MPM Capital")
     and in entities directly or indirectly controlled by it.  MPM Capital is a
     direct or indirect parent and/or a control person of MPM Asset Management
     LLC and funds managed or advised by it, and of the general partners of such
     funds.  Also includes shares held through interests in Medical Portfolio
     Management LLC, the general partner of MPM Capital.  Among the shares
     included, 2,690,912 shares are held by MPM BioVentures L.P.; 30,083 shares
     are held by MPM BioVentures Parallel Fund, L.P.; 4,792 shares are held by
     MPM Asset Management Investors 1998 LLC and 85,000 shares are shares
     issuable upon the exercise of options held by Ansbert S. Gadicke
     exercisable within 60 days of December 31, 2000.  Among such shares
     issuable upon the exercise of options held by Dr. Gadicke, 30,000 may also
     be beneficially owned by BB BioVentures L.P. and MPM BioVentures Parallel
     Fund, L.P., and 55,000 may also be beneficially owned by MPM Asset
     Management LLC.  Each reporting person herein disclaims beneficial
     ownership of shares not directly held by such reporting person.


                                   Signature
                                   ---------


     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Dated: February 14, 2001




                                                              

MPM CAPITAL L.P.                                                 BB BIOVENTURES L.P.

By:  Medical Portfolio Management LLC,                           By:  BAB BioVentures L.P.,
     its General Partner                                              its General Partner

                                                                 By:  BAB BioVentures N.V.,
                                                                      its General Partner
By:  /s/     Ansbert S. Gadicke
     -----------------------------------
     Name:  Ansbert S. Gadicke
     Title: Manager                                              By:  /s/     Ansbert S. Gadicke
                                                                      ----------------------------------
                                                                      Name:  Ansbert S. Gadicke
                                                                      Title: Manager



BAB BIOVENTURES L.P.                                             MPM BIOVENTURES PARALLEL FUND, L.P.

By:  BAB BioVentures, N.V.,                                      By:  MPM BioVentures I LP,
     its General Partner                                              its General Partner

By:  /s/     Ansbert S. Gadicke
     -----------------------------------                              By:  MPM BioVentures I LLC,
     Name:  Ansbert S. Gadicke                                        its General Partner
     Title: Manager

                                                                 By:  /s/     Ansbert S. Gadicke
                                                                      ----------------------------------
                                                                      Name:  Ansbert S. Gadicke
                                                                      Title: Manager



BAB BIOVENTURES, N.V.                                            MPM BIOVENTURES I LP

                                                                 By:  MPM BioVentures I LLC,
                                                                      its General Partner
By:  /s/     Ansbert S. Gadicke
     -----------------------------------
     Name:  Ansbert S. Gadicke
     Title:  Manager                                             By:  /s/     Ansbert S. Gadicke
                                                                      ----------------------------------
                                                                      Name:  Ansbert S. Gadicke
                                                                      Title: Manager





                                                                     
MPM BIOVENTURES I LLC                                                   MPM ASSET MANAGEMENT LLC



By:  /s/     Ansbert S. Gadicke                                  By:  /s/     Ansbert S. Gadicke
     -----------------------------------                             ----------------------------------
     Name:  Ansbert S. Gadicke                                        Name:  Ansbert S. Gadicke
     Title: Manager                                                   Title: Manager

MEDICAL PORTFOLIO MANAGEMENT, LLC                                MPM ASSET MANAGEMENT 1998 LLC


By:  /s/     Ansbert S. Gadicke
     -----------------------------------
     Name:   Ansbert S. Gadicke                                  By:  /s/     Ansbert S. Gadicke
     Title:  Manager                                                  ----------------------------------
                                                                      Name:  Ansbert S. Gadicke
                                                                      Title: Manager



                                   EXHIBIT A
                                   ---------

                            JOINT FILING AGREEMENT



        In accordance with Rule 13d-1(k) under the Securities Exchange Act of
1934, as amended, the undersigned agree to the joint filing on behalf of each of
them of a statement on Schedule 13G (including amendments thereto) with respect
to the Common Stock of BioMarin Pharmaceutical Inc. and further agree that this
agreement be included as an exhibit to such filing. Each party to the agreement
expressly authorizes each other party to file on its behalf any and all
amendments to such statement. Each party to this agreement agrees that this
joint filing agreement may be signed in counterparts.

        In evidence whereof, the undersigned have caused this Agreement to be
executed on their behalf this ___ day of February, 2001




                                                              

MPM CAPITAL L.P.                                                 BB BIOVENTURES L.P.

By:  Medical Portfolio Management LLC,                           By:  BAB BioVentures L.P.,
     its General Partner                                              its General Partner

                                                                 By:  BAB BioVentures N.V.,
                                                                      its General Partner
By:  /s/     Ansbert S. Gadicke
     -----------------------------------
     Name:  Ansbert S. Gadicke
     Title: Manager                                              By:  /s/     Ansbert S. Gadicke
                                                                      ----------------------------------
                                                                      Name:  Ansbert S. Gadicke
                                                                      Title: Manager



BAB BIOVENTURES L.P.                                             MPM BIOVENTURES PARALLEL FUND, L.P.

By:  BAB BioVentures, N.V.,                                      By:  MPM BioVentures I LP,
     its General Partner                                              its General Partner

By:  /s/     Ansbert S. Gadicke
     -----------------------------------                              By:  MPM BioVentures I LLC,
     Name:  Ansbert S. Gadicke                                        its General Partner
     Title: Manager

                                                                 By:  /s/     Ansbert S. Gadicke
                                                                      ----------------------------------
                                                                      Name:  Ansbert S. Gadicke
                                                                      Title: Manager



BAB BIOVENTURES, N.V.                                            MPM BIOVENTURES I LP

                                                                 By:  MPM BioVentures I LLC,
                                                                      its General Partner
By:  /s/     Ansbert S. Gadicke
     -----------------------------------
     Name:  Ansbert S. Gadicke
     Title: Manager                                              By:  /s/     Ansbert S. Gadicke
                                                                      ----------------------------------
                                                                      Name:  Ansbert S. Gadicke
                                                                      Title: Manager





                                                                     
MPM BIOVENTURES I LLC                                                   MPM ASSET MANAGEMENT LLC



By:  /s/     Ansbert S. Gadicke                                  By:  /s/     Ansbert S. Gadicke
     -----------------------------------                             ----------------------------------
     Name:  Ansbert S. Gadicke                                        Name:  Ansbert S. Gadicke
     Title: Manager                                                   Title: Manager

MEDICAL PORTFOLIO MANAGEMENT, LLC                                MPM ASSET MANAGEMENT 1998 LLC


By:  /s/     Ansbert S. Gadicke
     -----------------------------------
     Name:   Ansbert S. Gadicke                                  By:  /s/     Ansbert S. Gadicke
     Title:  Manager                                                  ----------------------------------
                                                                      Name:  Ansbert S. Gadicke
                                                                      Title: Manager