Ownership Submission
FORM 3
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  DeFonzo Joshua
2. Date of Event Requiring Statement (Month/Day/Year)
04/01/2015
3. Issuer Name and Ticker or Trading Symbol
CareDx, Inc. [CDNA]
(Last)
(First)
(Middle)
C/O CAREDX, INC., 3260 BAYSHORE BOULEVARD
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Chief Commercial Officer
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

BRISBANE, CA 94005
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 2,000 (1)
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(Month/Day/Year)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Employee Stock Option (right to buy)   (2) 09/12/2024 Common Stock 25,000 $ 10.12 D  
Employee Stock Option (right to buy)   (3) 03/06/2025 Common Stock 6,000 $ 6.49 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
DeFonzo Joshua
C/O CAREDX, INC.
3260 BAYSHORE BOULEVARD
BRISBANE, CA 94005
      Chief Commercial Officer  

Signatures

/s/ Kenneth Ludlum, by power of attorney 04/08/2015
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The reported securities are represented by restricted stock units which vest in four equal annual installments beginning on January 21, 2016.
(2) 1/4th of the shares subject to the option shall vest on September 12, 2015 and 1/48th of the shares subject to the option shall vest monthly thereafter.
(3) 1/4th of the shares subject to the option shall vest on March 06, 2016 and 1/48th of the shares subject to the option shall vest monthly thereafter.
 
Remarks:
Exhibit List:
Exhibit 24 - Power of Attorney

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