PAGE 1
000 A000000 03/31/2006
000 C000000 0001071899
000 D000000 N
000 E000000 NF
000 F000000 Y
000 G000000 N
000 H000000 N
000 I000000 6.1
000 J000000 A
001 A000000 MUNIHOLDINGS INSURED FUND II, INC.
001 B000000 811-9191
001 C000000 6092822800
002 A000000 P.O. BOX 9011
002 B000000 PRINCETON
002 C000000 NJ
002 D010000 08543
002 D020000 9011
003 000000 N
004 000000 N
005 000000 N
006 000000 N
007 A000000 N
007 B000000 0
007 C010100 1
007 C010200 2
007 C010300 3
007 C010400 4
007 C010500 5
007 C010600 6
007 C010700 7
007 C010800 8
007 C010900 9
007 C011000 10
008 A000001 FUND ASSET MANAGEMENT, L.P.
008 B000001 A
008 C000001 801-12485
008 D010001 PLAINSBORO
008 D020001 NJ
008 D030001 08536
011 A000001 MERRILL LYNCH, PIERCE, FENNER & SMITH INC.
011 B000001 8-7221
011 C010001 NEW YORK
011 C020001 NY
011 C030001 10281
011 C040001 1201
012 A000001 COMPUTERSHARE TRUST COMPANY, N.A. (COMMON)
012 B000001 85-11340
012 C010001 PROVIDENCE
012 C020001 RI
012 C030001 02940
012 C040001 3010
PAGE 2
012 A000002 THE BANK OF NEW YORK (PREFERRED)
012 B000002 85-05006
012 C010002 NEW YORK
012 C020002 NY
012 C030002 10286
013 A000001 ERNST & YOUNG LLP
013 B010001 PHILADELPHIA
013 B020001 PA
013 B030001 19103
013 B040001 7096
014 A000001 MLPF&S AND OTHER ML BROKER/DEALER AFFILIATES
014 B000001 8-7221
015 A000001 STATE STREET BANK AND TRUST COMPANY
015 B000001 C
015 C010001 BOSTON
015 C020001 MA
015 C030001 02101
015 E010001 X
015 A000002 BANKERS TRUST COMPANY
015 B000002 S
015 C010002 NEW YORK
015 C020002 NY
015 C030002 10006
015 E010002 X
015 A000003 J.P. MORGAN CHASE BANK
015 B000003 S
015 C010003 NEW YORK
015 C020003 NY
015 C030003 10017
015 E010003 X
015 A000004 CUSTODIAL TRUST CO.
015 B000004 S
015 C010004 NEW YORK
015 C020004 NY
015 C030004 10167
015 E010004 X
015 A000005 MORGAN GUARANTY TRUST CO. OF NEW YORK
015 B000005 S
015 C010005 NEW YORK
015 C020005 NY
015 C030005 10260
015 E010005 X
015 A000006 THE BANK OF NEW YORK
015 B000006 S
015 C010006 NEW YORK
015 C020006 NY
015 C030006 10286
015 E010006 X
018 000000 Y
019 A000000 Y
019 B000000 148
PAGE 3
019 C000000 MERRILLLYN
020 A000001 RBS GREENWICH CAPITAL
020 C000001 1
020 A000002 MERRILL LYNCH, PIERCE, FENNER & SMITH INC.
020 B000002 13-5674085
020 C000002 1
020 C000003 0
020 C000004 0
020 C000005 0
020 C000006 0
020 C000007 0
020 C000008 0
020 C000009 0
020 C000010 0
021 000000 2
022 A000001 MERRILL LYNCH INSTITUTIONAL TAX-EXEMPT FUND
022 B000001 22-2509978
022 C000001 74200
022 D000001 74500
022 A000002 J.P. MORGAN SECURITIES INC.
022 B000002 13-3224016
022 C000002 58137
022 D000002 69107
022 A000003 CITIGROUP GLOBAL MARKETS INC.
022 B000003 11-2418191
022 C000003 15194
022 D000003 6692
022 A000004 MURIEL SIEBERT & CO., INC.
022 C000004 12923
022 D000004 8001
022 A000005 MORGAN STANLEY
022 B000005 13-2655998
022 C000005 15580
022 D000005 3796
022 A000006 GOLDMAN, SACHS & CO.
022 B000006 13-5108880
022 C000006 8379
022 D000006 2706
022 A000007 BANC OF AMERICA SECURITIES LLC
022 B000007 56-2058405
022 C000007 2017
022 D000007 7982
022 A000008 RBC DAIN RAUSCHER INC.
022 B000008 41-0212020
022 C000008 3344
022 D000008 5988
022 A000009 PIPER JAFFRAY & CO.
022 B000009 41-0953246
022 C000009 4016
022 D000009 4038
022 A000010 UBS SECURITIES LLC
PAGE 4
022 B000010 13-3873456
022 C000010 0
022 D000010 7400
023 C000000 212637
023 D000000 206325
024 000000 N
026 A000000 N
026 B000000 Y
026 C000000 N
026 D000000 Y
026 E000000 N
026 F000000 N
026 G010000 N
026 G020000 N
026 H000000 N
027 000000 N
045 000000 Y
046 000000 N
047 000000 Y
048 000000 0.550
048 A010000 0
048 A020000 0.000
048 B010000 0
048 B020000 0.000
048 C010000 0
048 C020000 0.000
048 D010000 0
048 D020000 0.000
048 E010000 0
048 E020000 0.000
048 F010000 0
048 F020000 0.000
048 G010000 0
048 G020000 0.000
048 H010000 0
048 H020000 0.000
048 I010000 0
048 I020000 0.000
048 J010000 0
048 J020000 0.000
048 K010000 0
048 K020000 0.000
049 000000 N
050 000000 N
051 000000 N
052 000000 N
053 A000000 Y
053 B000000 Y
053 C000000 N
054 A000000 Y
054 B000000 Y
PAGE 5
054 C000000 N
054 D000000 N
054 E000000 N
054 F000000 N
054 G000000 N
054 H000000 Y
054 I000000 N
054 J000000 Y
054 K000000 N
054 L000000 N
054 M000000 Y
054 N000000 N
055 A000000 Y
055 B000000 N
056 000000 Y
057 000000 N
058 A000000 N
059 000000 Y
060 A000000 N
060 B000000 N
061 000000 0
062 A000000 Y
062 B000000 0.0
062 C000000 0.0
062 D000000 0.0
062 E000000 0.2
062 F000000 0.0
062 G000000 0.0
062 H000000 0.0
062 I000000 0.0
062 J000000 0.0
062 K000000 0.0
062 L000000 0.0
062 M000000 0.0
062 N000000 0.0
062 O000000 163.0
062 P000000 0.0
062 Q000000 0.0
062 R000000 1.1
063 A000000 0
063 B000000 15.5
064 A000000 Y
064 B000000 N
066 A000000 N
067 000000 N
068 A000000 N
068 B000000 N
069 000000 N
070 A010000 Y
070 A020000 N
070 B010000 N
PAGE 6
070 B020000 N
070 C010000 Y
070 C020000 N
070 D010000 N
070 D020000 N
070 E010000 Y
070 E020000 Y
070 F010000 N
070 F020000 N
070 G010000 Y
070 G020000 N
070 H010000 N
070 H020000 N
070 I010000 N
070 I020000 N
070 J010000 Y
070 J020000 N
070 K010000 Y
070 K020000 Y
070 L010000 N
070 L020000 N
070 M010000 N
070 M020000 N
070 N010000 N
070 N020000 N
070 O010000 Y
070 O020000 N
070 P010000 Y
070 P020000 Y
070 Q010000 N
070 Q020000 N
070 R010000 N
070 R020000 N
071 A000000 125037
071 B000000 129177
071 C000000 510702
071 D000000 24
072 A000000 6
072 B000000 12270
072 C000000 59
072 D000000 0
072 E000000 0
072 F000000 1422
072 G000000 86
072 H000000 0
072 I000000 33
072 J000000 14
072 K000000 0
072 L000000 20
072 M000000 13
072 N000000 0
PAGE 7
072 O000000 0
072 P000000 0
072 Q000000 0
072 R000000 21
072 S000000 9
072 T000000 0
072 U000000 0
072 V000000 0
072 W000000 301
072 X000000 1919
072 Y000000 102
072 Z000000 10512
072AA000000 2302
072BB000000 714
072CC010000 0
072CC020000 6461
072DD010000 9120
072DD020000 0
072EE000000 0
073 A010000 0.4080
073 A020000 0.0000
073 B000000 0.0000
073 C000000 0.0000
074 A000000 42
074 B000000 0
074 C000000 500
074 D000000 508039
074 E000000 0
074 F000000 0
074 G000000 0
074 H000000 0
074 I000000 3303
074 J000000 176
074 K000000 0
074 L000000 7503
074 M000000 8
074 N000000 519571
074 O000000 3011
074 P000000 214
074 Q000000 0
074 R010000 0
074 R020000 0
074 R030000 0
074 R040000 208
074 S000000 204577
074 T000000 311561
074 U010000 22352
074 U020000 0
074 V010000 13.94
074 V020000 0.00
074 W000000 0.0000
PAGE 8
074 X000000 3870
074 Y000000 511828
075 A000000 0
075 B000000 518438
076 000000 13.32
077 A000000 Y
077 O000000 Y
078 000000 N
086 A010000 0
086 A020000 0
086 B010000 0
086 B020000 0
086 C010000 0
086 C020000 0
086 D010000 0
086 D020000 0
086 E010000 0
086 E020000 0
086 F010000 0
086 F020000 0
087 A010000 COMMON STOCK
087 A020000 62625A102
087 A030000 MUE
087 B010000 PREFERRED STOCK
088 A000000 N
088 B000000 N
088 C000000 N
088 D000000 Y
SIGNATURE DONALD C. BURKE
TITLE TREASURER