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                               UNITED STATES
                     SECURITIES AND EXCHANGE COMMISSION
                           WASHINGTON, D.C. 20549


                                SCHEDULE 13G
                             (AMENDMENT NO. 1)

                 UNDER THE SECURITIES EXCHANGE ACT OF 1934

                               Nuvelo, Inc.
------------------------------------------------------------------------------
                              (Name of Issuer)

                      Common Stock, $0.001 par value
------------------------------------------------------------------------------
                       (Title of Class of Securities)

                                 67072M301
                     ---------------------------------
                               (CUSIP Number)


                               December 31, 2005
                     ---------------------------------
          (Date of Event which Requires Filing of this Statement)



Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:

                      |_| Rule 13d-1(b)

                      |X| Rule 13d-1(c)

                      |_| Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which
would alter disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities
Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of
that section of the Act but shall be subject to all other provisions of the
Act (however, see the Notes).



----------------------                         -------------------------------
CUSIP NO. 67072M301                13G                  PAGE 2 OF 10 PAGES
----------------------                         -------------------------------


------------------------------------------------------------------------------
   1    NAMES OF REPORTING PERSONS
        I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
                       Ziff Asset Management, L.P.

------------------------------------------------------------------------------
   2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
        (SEE INSTRUCTIONS)                                             (A) |_|
                                                                       (B) |_|

------------------------------------------------------------------------------
   3    SEC USE ONLY

------------------------------------------------------------------------------
   4    CITIZENSHIP OR PLACE OF ORGANIZATION

                       Delaware

------------------------------------------------------------------------------
                     5    SOLE VOTING POWER

     NUMBER OF                    0
       SHARES
                    ----------------------------------------------------------
                     6    SHARED VOTING POWER
    BENEFICIALLY
                                  3,912,670
      OWNED BY
                    ----------------------------------------------------------
        EACH         7    SOLE DISPOSITIVE POWER

                                  0
     REPORTING
                    ----------------------------------------------------------
       PERSON        8    SHARED DISPOSITIVE POWER
        WITH
                                   3,912,670

------------------------------------------------------------------------------
   9    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                 3,912,670

------------------------------------------------------------------------------
  10    CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
        (SEE INSTRUCTIONS)                                                 |_|

------------------------------------------------------------------------------
  11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                9.3%

------------------------------------------------------------------------------
  12    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

                PN

------------------------------------------------------------------------------



----------------------                         -------------------------------
CUSIP NO. 67072M301                13G                  PAGE 3 OF 10 PAGES
----------------------                         -------------------------------

------------------------------------------------------------------------------
   1    NAMES OF REPORTING PERSONS
        I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
                       PBK Holdings, Inc.

------------------------------------------------------------------------------
   2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
        (SEE INSTRUCTIONS)                                             (A) |_|
                                                                       (B) |_|

------------------------------------------------------------------------------
   3    SEC USE ONLY

------------------------------------------------------------------------------
   4    CITIZENSHIP OR PLACE OF ORGANIZATION

                       Delaware

------------------------------------------------------------------------------
                     5    SOLE VOTING POWER

     NUMBER OF                    0
       SHARES
                    ----------------------------------------------------------
                     6    SHARED VOTING POWER
    BENEFICIALLY
                                  3,912,670
      OWNED BY
                    ----------------------------------------------------------
        EACH         7    SOLE DISPOSITIVE POWER

                                  0
     REPORTING
                    ----------------------------------------------------------
       PERSON        8    SHARED DISPOSITIVE POWER
        WITH
                                   3,912,670

------------------------------------------------------------------------------
   9    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                 3,912,670

------------------------------------------------------------------------------
  10    CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
        (SEE INSTRUCTIONS)                                                 |_|

------------------------------------------------------------------------------
  11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                9.3%

------------------------------------------------------------------------------
  12    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

                CO

------------------------------------------------------------------------------



----------------------                         -------------------------------
CUSIP NO.  67072M301               13G                  PAGE 4 OF 10 PAGES
----------------------                         -------------------------------

------------------------------------------------------------------------------
   1    NAMES OF REPORTING PERSONS
        I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
                       Philip B. Korsant

------------------------------------------------------------------------------
   2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
        (SEE INSTRUCTIONS)                                             (A) |_|
                                                                       (B) |_|

------------------------------------------------------------------------------
   3    SEC USE ONLY

------------------------------------------------------------------------------
   4    CITIZENSHIP OR PLACE OF ORGANIZATION

                       United States of America

------------------------------------------------------------------------------
                     5    SOLE VOTING POWER

     NUMBER OF                    0
       SHARES
                    ----------------------------------------------------------
                     6    SHARED VOTING POWER
    BENEFICIALLY
                                  3,912,670
      OWNED BY
                    ----------------------------------------------------------
        EACH         7    SOLE DISPOSITIVE POWER

                                  0
     REPORTING
                    ----------------------------------------------------------
       PERSON        8    SHARED DISPOSITIVE POWER
        WITH
                                  3,912,670

------------------------------------------------------------------------------
   9    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                3,912,670

------------------------------------------------------------------------------
  10    CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
        (SEE INSTRUCTIONS)                                                 |_|

------------------------------------------------------------------------------
  11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                9.3%

------------------------------------------------------------------------------
  12    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

                IN

------------------------------------------------------------------------------


----------------------                         -------------------------------
CUSIP NO.  67072M301               13G                  PAGE 5 OF 10 PAGES
----------------------                         -------------------------------

------------------------------------------------------------------------------
   1    NAMES OF REPORTING PERSONS
        I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
                       ZBI Equities, L.L.C.

------------------------------------------------------------------------------
   2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
        (SEE INSTRUCTIONS)                                             (A) |_|
                                                                       (B) |_|

------------------------------------------------------------------------------
   3    SEC USE ONLY

------------------------------------------------------------------------------
   4    CITIZENSHIP OR PLACE OF ORGANIZATION

                       Delaware

------------------------------------------------------------------------------
                     5    SOLE VOTING POWER

     NUMBER OF                    0
       SHARES
                    ----------------------------------------------------------
                     6    SHARED VOTING POWER
    BENEFICIALLY
                                   3,912,670
      OWNED BY
                    ----------------------------------------------------------
        EACH         7    SOLE DISPOSITIVE POWER

                                  0
     REPORTING
                    ----------------------------------------------------------
       PERSON        8    SHARED DISPOSITIVE POWER
        WITH
                                   3,912,670

------------------------------------------------------------------------------
   9    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                 3,912,670

------------------------------------------------------------------------------
  10    CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
        (SEE INSTRUCTIONS)                                                 |_|

------------------------------------------------------------------------------
  11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                 9.3%

------------------------------------------------------------------------------
  12    TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

                 IA

------------------------------------------------------------------------------



ITEM 1. (a)    NAME OF ISSUER

Nuvelo, Inc.

ITEM 1. (b)    ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES

201 Industrial Road
Suite 310
San Carlos, CA 94070-6211

ITEM 2. (a)    NAME OF PERSON FILING

This Schedule 13G is being filed on behalf of the following persons (the
"Reporting Persons")*:

(i)     Ziff Asset Management, L.P. ("ZAM");
(ii)    PBK Holdings, Inc. ("PBK");
(iii)   Philip B. Korsant; and
(iv)    ZBI Equities, L.L.C. ("ZBI");

*       Attached as Exhibit A is a copy of an agreement among the Reporting
Persons that this Schedule 13G is being filed on behalf of each of them.

ITEM 2. (b)    ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE

Ziff Asset Management, L.P.
283 Greenwich Avenue
Greenwich, CT  06830

PBK Holdings, Inc.
283 Greenwich Avenue
Greenwich, CT  06830

Philip B. Korsant
283 Greenwich Avenue
Greenwich, CT  06830

ZBI Equities, L.L.C.
283 Greenwich Avenue
Greenwich, CT  06830

ITEM 2. (c)    CITIZENSHIP

See Item 4 of the attached cover pages.

ITEM 2. (d)    TITLE OF CLASS OF SECURITIES

Common Stock, $0.001 par value (the "Common Stock")

ITEM 2. (e)    CUSIP NUMBER

67072M301

ITEM 3.

Not applicable as this Schedule 13G is filed pursuant to Rule 13d-1(c).

ITEM 4. OWNERSHIP

(a)     Amount beneficially owned:

        See Item 9 of the attached cover pages.

(b)     Percent of class:

        See Item 11 of the attached cover pages.

(c)     Number of shares as to which such person has:

        (i)    Sole power to vote or to direct the vote:

               See Item 5 of the attached cover pages.

        (ii)   Shared power to vote or to direct the vote:

               See Item 6 of the attached cover pages.

        (iii)  Sole power to dispose or to direct the disposition:

               See Item 7 of the attached cover pages.

        (iv)   Shared power to dispose or to direct the disposition:

               See Item 8 of the attached cover pages.

ITEM 5.        OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

Not Applicable.

ITEM 6.        OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON

ZAM is the owner of record of the shares of Common Stock reported herein.
Each of PBK, Philip B. Korsant, and ZBI may be deemed to beneficially own the
Common Stock reported herein as a result of the direct or indirect power to
vote or dispose of such stock.

ITEM 7.        IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH
               ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING
               COMPANY

Not Applicable.

ITEM 8.        IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP

Not Applicable.

ITEM 9.        NOTICE OF DISSOLUTION OF GROUP

Not Applicable.

ITEM 10.       CERTIFICATION

By signing  below I certify  that,  to the best of my knowledge and belief,
the securities referred to above were not acquired and are not held for the
purpose of or with the effect of changing or influencing the control of the
issuer  of the  securities  and  were  not  acquired  and are  not  held in
connection with or as a participant in any transaction  having that purpose
or effect.



                                  SIGNATURE


     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true,  complete
and correct.

Dated:  February 13, 2006


                                    ZIFF ASSET MANAGEMENT, L.P.
                                    By:PBK Holdings, Inc., its general partner


                                    By:/s/ DAVID GRAY
                                       -----------------------------
                                       Name:  David Gray
                                       Title: Vice President


                                    PBK HOLDINGS, INC.


                                    By:/s/ DAVID GRAY
                                       ------------------------------
                                       Name:  David Gray
                                       Title: Vice President


                                        /s/ PHILIP B. KORSANT
                                       ------------------------------
                                            Philip B. Korsant


                                    ZBI EQUITIES, L.L.C.
                                    By:PBK Holdings, Inc., its sole member


                                    By:/s/ DAVID GRAY
                                       ------------------------------
                                       Name:  David Gray
                                       Title: Vice President






                                  EXHIBIT A


     The  undersigned,  Ziff Asset  Management,  L.P.,  a Delaware  limited
partnership, PBK Holdings, Inc., a Delaware corporation, Philip B. Korsant,
and ZBI Equities,  L.L.C., a Delaware  limited  liability  company,  hereby
agree and acknowledge  that the information  required by this Schedule 13G,
to which this  Agreement  is attached as an exhibit,  is filed on behalf of
each of them. The undersigned  further agree that any further amendments or
supplements thereto shall also be filed on behalf of each of them.

Dated:  February 13, 2006


                                    ZIFF ASSET MANAGEMENT, L.P.
                                    By:PBK Holdings, Inc., its general partner


                                    By:/s/ DAVID GRAY
                                       -----------------------------
                                       Name:  David Gray
                                       Title: Vice President


                                    PBK HOLDINGS, INC.


                                    By:/s/ DAVID GRAY
                                       ------------------------------
                                       Name:  David Gray
                                       Title: Vice President


                                        /s/ PHILIP B. KORSANT
                                       ------------------------------
                                            Philip B. Korsant


                                    ZBI EQUITIES, L.L.C.
                                    By:PBK Holdings, Inc., its sole member


                                    By:/s/ DAVID GRAY
                                       ------------------------------
                                       Name:  David Gray
                                       Title: Vice President