SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                ----------------

                                 SCHEDULE 13G/A
                                 (Rule 13d-102)
                                ----------------

    INFORMATION TO BE INCLUDED IN STATEMENTS PURSUANT TO RULES 13d-1(b), (c)
             AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2
                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                         (Amendment No. _____________)*


                                   NUVELO INC.
                                (Name of Issuer)

                          Common Stock, $.01 par value
                         (Title of Class of Securities)

                                    67072M103
                                 (CUSIP Number)


                                December 31, 2003
             (Date of Event Which Requires Filing of this Statement)


     Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:
       [ ] Rule 13d-1(b)
       [X] Rule 13d-1(c)
       [ ] Rule 13d-1(d)

-----------

     * The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.


     The information required in the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).




Schedule 13G/A                                                   PAGE 2 OF 16

CUSIP No. 67072M103
-----------------------------------------------------------------------------
     (1)  NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
               CLSP, L.P.
-----------------------------------------------------------------------------
     (2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a) [ ]
                                                                    (b) [x]
-----------------------------------------------------------------------------
     (3)  SEC USE ONLY

-----------------------------------------------------------------------------
     (4)  CITIZENSHIP OR PLACE OF ORGANIZATION
               Delaware
-----------------------------------------------------------------------------

NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                    1,467,824
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    1,467,824
-----------------------------------------------------------------------------
     (9)  AGGREGATE AMOUNT BENEFICIALLY OWNED
          BY EACH REPORTING PERSON
                 1,467,824
-----------------------------------------------------------------------------
    (10)  CHECK BOX IF THE AGGREGATE AMOUNT
          IN ROW (9) EXCLUDES CERTAIN SHARES                             [ ]
-----------------------------------------------------------------------------
    (11)  PERCENT OF CLASS REPRESENTED
          BY AMOUNT IN ROW (9)
               1.9%
-----------------------------------------------------------------------------
    (12)  TYPE OF REPORTING PERSON
               PN
-----------------------------------------------------------------------------




Schedule 13G/A                                                   PAGE 3 OF 16

CUSIP No. 67072M103
-----------------------------------------------------------------------------
     (1)  NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
          CLSP II, L.P.
-----------------------------------------------------------------------------
     (2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a) [ ]
                                                                    (b) [x]
-----------------------------------------------------------------------------
     (3)  SEC USE ONLY

-----------------------------------------------------------------------------
     (4)  CITIZENSHIP OR PLACE OF ORGANIZATION
                  Delaware
-----------------------------------------------------------------------------

NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                    1,875,066
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    1,875,066
-----------------------------------------------------------------------------
     (9)  AGGREGATE AMOUNT BENEFICIALLY OWNED
          BY EACH REPORTING PERSON
                 1,875,066
-----------------------------------------------------------------------------
    (10)  CHECK BOX IF THE AGGREGATE AMOUNT
          IN ROW (9) EXCLUDES CERTAIN SHARES                             [ ]
-----------------------------------------------------------------------------
    (11)  PERCENT OF CLASS REPRESENTED
          BY AMOUNT IN ROW (9)
                 2.4%
-----------------------------------------------------------------------------
    (12)  TYPE OF REPORTING PERSON
                 PN
-----------------------------------------------------------------------------




Schedule 13G/A                                                   PAGE 4 OF 16

CUSIP No. 67072M103
-----------------------------------------------------------------------------
     (1)  NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
          CLSP/SBS I, L.P.
-----------------------------------------------------------------------------
     (2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a) [ ]
                                                                    (b) [x]
-----------------------------------------------------------------------------
     (3)  SEC USE ONLY

-----------------------------------------------------------------------------
     (4)  CITIZENSHIP OR PLACE OF ORGANIZATION
                Delaware
-----------------------------------------------------------------------------

NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                    569,048
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    569,048
-----------------------------------------------------------------------------
     (9)  AGGREGATE AMOUNT BENEFICIALLY OWNED
          BY EACH REPORTING PERSON
                 569,048
-----------------------------------------------------------------------------
    (10)  CHECK BOX IF THE AGGREGATE AMOUNT
          IN ROW (9) EXCLUDES CERTAIN SHARES                             [ ]
-----------------------------------------------------------------------------
    (11)  PERCENT OF CLASS REPRESENTED
          BY AMOUNT IN ROW (9)
                 0.7%
-----------------------------------------------------------------------------
    (12)  TYPE OF REPORTING PERSON
                 PN
-----------------------------------------------------------------------------




Schedule 13G/A                                                   PAGE 5 OF 16
CUSIP No. 67072M103
-----------------------------------------------------------------------------
     (1)  NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
          CLSP/SBS II, L.P.
-----------------------------------------------------------------------------
     (2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a) [ ]
                                                                    (b) [x]
-----------------------------------------------------------------------------
     (3)  SEC USE ONLY

-----------------------------------------------------------------------------
     (4)  CITIZENSHIP OR PLACE OF ORGANIZATION
                  Delaware
-----------------------------------------------------------------------------

NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                    171,799
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    171,799
-----------------------------------------------------------------------------
     (9)  AGGREGATE AMOUNT BENEFICIALLY OWNED
          BY EACH REPORTING PERSON
                 171,799
-----------------------------------------------------------------------------
    (10) CHECK BOX IF THE AGGREGATE AMOUNT
          IN ROW (9) EXCLUDES CERTAIN SHARES                             [ ]
-----------------------------------------------------------------------------
    (11)  PERCENT OF CLASS REPRESENTED
          BY AMOUNT IN ROW (9)
                 0.2%
-----------------------------------------------------------------------------
    (12)  TYPE OF REPORTING PERSON
                 PN
-----------------------------------------------------------------------------




Schedule 13G/A                                                   PAGE 6 OF 16
CUSIP No. 67072M103
-----------------------------------------------------------------------------
     (1)  NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                 Cooper Hill Partners, L.P.
-----------------------------------------------------------------------------
     (2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a) [ ]
                                                                    (b) [x]
-----------------------------------------------------------------------------
     (3)  SEC USE ONLY

-----------------------------------------------------------------------------
     (4)  CITIZENSHIP OR PLACE OF ORGANIZATION
                 Delaware
-----------------------------------------------------------------------------

NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                    1,344,741
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    1,344,741
-----------------------------------------------------------------------------
     (9)  AGGREGATE AMOUNT BENEFICIALLY OWNED
          BY EACH REPORTING PERSON
                 1,344,741
-----------------------------------------------------------------------------
    (10) CHECK BOX IF THE AGGREGATE AMOUNT
          IN ROW (9) EXCLUDES CERTAIN SHARES                             [ ]
-----------------------------------------------------------------------------
    (11)  PERCENT OF CLASS REPRESENTED
          BY AMOUNT IN ROW (9)
                 1.7%
-----------------------------------------------------------------------------
    (12)  TYPE OF REPORTING PERSON
                 PN
-----------------------------------------------------------------------------




Schedule 13G/A                                                   PAGE 7 OF 16

CUSIP No. 67072M103
-----------------------------------------------------------------------------
     (1)  NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                 Cooper Hill Partners, LLC
-----------------------------------------------------------------------------
     (2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a) [ ]
                                                                    (b) [x]
-----------------------------------------------------------------------------
     (3)  SEC USE ONLY

-----------------------------------------------------------------------------
     (4)  CITIZENSHIP OR PLACE OF ORGANIZATION
                 Delaware
-----------------------------------------------------------------------------

NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                    4,083,737
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    4,083,737
-----------------------------------------------------------------------------
     (9)  AGGREGATE AMOUNT BENEFICIALLY OWNED
          BY EACH REPORTING PERSON
               4,083,737
-----------------------------------------------------------------------------
    (10)  CHECK BOX IF THE AGGREGATE AMOUNT
          IN ROW (9) EXCLUDES CERTAIN SHARES                             [ ]
-----------------------------------------------------------------------------
    (11)  PERCENT OF CLASS REPRESENTED
          BY AMOUNT IN ROW (9)
               5.3%
-----------------------------------------------------------------------------
    (12)  TYPE OF REPORTING PERSON
               OO
-----------------------------------------------------------------------------




Schedule 13G/A                                                   PAGE 8 OF 16

CUSIP No. 67072M103
---------------------------------------------------------------------------
     (1)  NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                 Casdin Capital, L.L.C.
-----------------------------------------------------------------------------
     (2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a) [ ]
                                                                    (b) [x]
-----------------------------------------------------------------------------
     (3)  SEC USE ONLY

-----------------------------------------------------------------------------
     (4)  CITIZENSHIP OR PLACE OF ORGANIZATION
                 Delaware
-----------------------------------------------------------------------------

NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                    5,428,478
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                    5,428,478
-----------------------------------------------------------------------------
     (9)  AGGREGATE AMOUNT BENEFICIALLY OWNED
          BY EACH REPORTING PERSON
                 5,428,478
-----------------------------------------------------------------------------
    (10)  CHECK BOX IF THE AGGREGATE AMOUNT
          IN ROW (9) EXCLUDES CERTAIN SHARES                             [ ]
-----------------------------------------------------------------------------
    (11)  PERCENT OF CLASS REPRESENTED
          BY AMOUNT IN ROW (9)
                 7.1%
-----------------------------------------------------------------------------
    (12)  TYPE OF REPORTING PERSON
                 OO
-----------------------------------------------------------------------------







Schedule 13G/A                                                   PAGE 9 of 16

CUSIP No. 67072M103
-----------------------------------------------------------------------------
     (1)  NAME OF REPORTING PERSON
          S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
                 Jeffrey Casdin
-----------------------------------------------------------------------------
     (2)  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
                                                                    (a) [ ]
                                                                    (b) [x]
-----------------------------------------------------------------------------
     (3)  SEC USE ONLY

-----------------------------------------------------------------------------
     (4)  CITIZENSHIP OR PLACE OF ORGANIZATION
                 United States
-----------------------------------------------------------------------------

NUMBER OF      (5)  SOLE VOTING POWER
                    0
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                         5,428,478
OWNED BY       ______________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER
                    0
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER
                         5,428,478
-----------------------------------------------------------------------------
     (9)  AGGREGATE AMOUNT BENEFICIALLY OWNED
          BY EACH REPORTING PERSON
                         5,428,478
-----------------------------------------------------------------------------
    (10)  CHECK BOX IF THE AGGREGATE AMOUNT
          IN ROW (9) EXCLUDES CERTAIN SHARES                             [ ]
-----------------------------------------------------------------------------
    (11)  PERCENT OF CLASS REPRESENTED
          BY AMOUNT IN ROW (9)
                 7.1%
-----------------------------------------------------------------------------
    (12)  TYPE OF REPORTING PERSON
                 IN
-----------------------------------------------------------------------------





Schedule 13G/A                                                  PAGE 10 OF 16

ITEM 1(a).  NAME OF ISSUER:
                 NUVELO INC.

ITEM 1(b).  ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:
                 675 Almanor Avenue Sunnyvale, CA 94085

ITEM 2(a).  NAME OF PERSON FILING:

     This statement is filed by:
          (i) CLSP, L.P. ("CLSP"),
              a Delaware limited partnership, with respect to the Securities
              owned by it;
         (ii) CLSP II, L.P. ("CLSP II") a Delaware limited partnership, with
              respect to the Securities owned by it;
        (iii) CLSP/SBS I, L.P. ("CLSP/SBS I") a Delaware limited partnership,
              with respect to the Securities owned by it;
         (iv) CLSP/SBS II, L.P. ("CLSP/SBS II") a Delaware limited partnership,
              with respect to the Securities owned by it;
          (v) Cooper Hill Partners, L.P., a Delaware limited partnership with
              respect to the Securities held for CLSP Overseas, Ltd. ("CLSP
              Overseas"), [a Cayman Islands exempted company];
         (vi) Cooper Hill Partners, LLC ("Cooper, LLC "), a Delaware limited
              liability company and the sole general partner of CLSP, CLSP II,
              CLSP/SBS I AND CLSP/SBS II with respect to the Securities owned by
              CLSP, CLSP II, CLSP/SBS I AND CLSP/SBS II;
        (vii) Casdin Capital, L.L.C. ("Casdin, LLC "), a Delaware limited
              liability company and the sole general partner of Cooper Hill
              Partners, L.P. and the managing member to Cooper, LLC with respect
              to the Securities owned by CLSP, CLSP II, CLSP/SBS I AND CLSP/SBS
              II and CLSP Overseas; and
       (viii) Jeffrey Casdin a citizen of the United States, and the Managing
              Member of Casdin Capital, LLC, the general partner of Cooper Hill
              Partners, L.P. and the managing member of Cooper LLC, with respect
              to Securities subject to the control of Cooper LLC and Cooper Hill
              Partners, LP.

              The foregoing persons (other than CLSP Overseas) are hereinafter
              sometimes collectively referred to as the "Reporting Persons." Any
              disclosures herein with respect to persons other than the
              Reporting Persons are made on information and belief after making
              inquiry to the appropriate party.





Schedule 13G/A                                                  PAGE 11 OF 16

ITEM 2(b).  ADDRESS OF PRINCIPAL OFFICE OR, IF NONE, RESIDENCE:
            The business address of each of the Reporting Persons is 767 Third
Avenue, 22nd Floor, New York, New York 10077. The business address of CLSP
Overseas is c/o Goldman Sachs (Cayman) Trust, Limited P.O. Box 896 G.T. Harbour
Centre, Second Floor North Church Street George Town, Grand Cayman Cayman
Islands, B.W.I.

ITEM 2(c).  CITIZENSHIP:
             Cooper, LLC and Casdin, LLC are Delaware limited liability
companies and CLSP, CLSP II, CLSP/SBS I, CLSP/SBS II and Cooper Hill Partners,
L.P. are each a Delaware limited partnership. CLSP Overseas is a Cayman Islands
exempted company. Jeffrey Casdin is a citizen of the United States.

ITEM 2(d).  TITLE OF CLASS OF SECURITIES: Common Stock, $.01 par value

ITEM 2(e).  CUSIP NUMBER:                 67072M103

ITEM 3. IF THIS STATEMENT IS FILED PURSUANT TO 13d-1(b) OR 13d-2(b) OR (c),
CHECK WHETHER THE PERSON FILING IS A:

          (a)   [ ] Broker or dealer registered under Section 15 of the Act

          (b)   [ ] Bank as defined in Section 3(a)(6) of the Act

          (c)   [ ] Insurance Company as defined in Section 3(a)(19) of the
                    Act

          (d)   [ ] Investment Company registered under Section 8 of the
                    Investment Company Act of 1940

          (e)   [ ] Investment Adviser registered under Section 203 of the
                    Investment Advisers Act of 1940: see Rule 13d-
                    1(b)(1)(ii)(E)

          (f)   [ ] Employee Benefit Plan, Pension Fund which is subject to
                    the provisions of the Employee Retirement Income Security
                    Act of 1974 or Endowment Fund; see Rule 13d- 1(b)(1)(ii)(F)

          (g)   [ ] Parent Holding Company, in accordance with Rule 13d-
                    1(b)(ii)(G);

          (h)   [ ] Savings Associations as defined in Section 3(b) of the
                    Federal Deposit Insurance Act;

          (i)   [ ] Church Plan that is excluded from the definition of an
                    investment company under Section 3(c)(14) of the Investment
                    Company Act of 1940;



Schedule 13G/A                                                  PAGE 12 OF 16

          (j) ( ) Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

     IF THIS STATEMENT IS FILED PURSUANT TO Rule 13d-1(c), CHECK THIS BOX. [x]


ITEM 4.   OWNERSHIP.
     A.  CLSP
        (a) Amount beneficially owned: 1,467,824
        (b) Percent of class: 1.9%
          (All percentages herein are based on 76,863,705 shares of Common Stock
          reported to be outstanding as of December 31, 2003, as reflected in
          the Company's quarterly report on Form S-3 filed with the Securities
          and Exchange Commission by the Company for the quarter ended January
          26, 2004).
        (c) Number of shares as to which such person has:
                  (i)    sole power to vote or to direct the vote
                         0
                  (ii)   shared power to vote or to direct the vote
                         1,467,824
                  (iii)  sole power to dispose or to direct the disposition of
                         0
                  (iv)   shared power to dispose or to direct the disposition of
                         1,467,824

B. CLSP II
        (a) Amount beneficially owned: 1,875,066
        (b) Percent of class: 2.4%
        (c) Number of shares as to which such person has:
                  (i)    sole power to vote or to direct the vote
                         0
                  (ii)   shared power to vote or to direct the vote
                         1,875,066
                  (iii)  sole power to dispose or to direct the disposition of
                         0
                  (iv)   shared power to dispose or to direct the disposition of
                         1,875,066

     C. CLSP/SBS I
        (a) Amount beneficially owned: 569,048
        (b) Percent of class: 0.7%
        (c) Number of shares as to which such person has:
                  (i)    sole power to vote or to direct the vote
                         0
                  (ii)   shared power to vote or to direct the vote
                         569,048
                  (iii)  sole power to dispose or to direct the disposition of
                         0




  Schedule 13G/A                                                  PAGE 13 OF 16

                  (iv)   shared power to dispose or to direct the disposition of
                         569,048

     D. CLSP/SBS II
        (a) Amount beneficially owned: 171,799
        (b) Percent of class: 0.2%
        (c) Number of shares as to which such person has:
                  (i)    sole power to vote or to direct the vote
                         0
                  (ii)   shared power to vote or to direct the vote
                         171,799
                 (iii)   sole power to dispose or to direct the disposition of
                         0
                  (iv)   shared power to dispose or to direct the disposition of
                         171,799

     E. Cooper Hill Partners, L.P.
        (a) Amount beneficially owned: 1,344,741
        (b)Percent of class: 1.7%
        (c) Number of shares as to which such person has:
                  (i)    sole power to vote or to direct the vote
                         0
                  (ii)   shared power to vote or to direct the vote
                         1,344,741
                  (iii)  sole power to dispose or to direct the disposition of
                         0
                  (iv)   shared power to dispose or to direct the disposition of
                         1,344,741

     F. Cooper, LLC
        (a) Amount beneficially owned: 4,083,737
        (b) Percent of class: 5.3%
        (c) Number of shares as to which such person has:
                  (i)    sole power to vote or to direct the vote
                         0
                  (ii)   shared power to vote or to direct the vote
                         4,083,737
                  (iii)  sole power to dispose or to direct the disposition of
                         0
                  (iv)   shared power to dispose or to direct the disposition of
                         4,083,737



Schedule 13G/A                                                  PAGE 14 OF 16

     G. Casdin, LLC
        (a) Amount beneficially owned: 5,428,478
        (b) Percent of class: 7.1%
        (c) Number of shares as to which such person has:
                  (i)    sole power to vote or to direct the vote
                         0
                  (ii)   shared power to vote or to direct the vote
                         5,428,478
                 (iii)   sole power to dispose or to direct the disposition of
                         0
                  (iv)   shared power to dispose or to direct the disposition of
                         5,428,478

     H. Jeffrey Casdin
        (a) Amount beneficially owned: 5,428,478
        (c) Percent of class:  7.1%
        (c) Number of shares as to which such person has:
                  (i)    sole power to vote or to direct the vote
                         0
                  (ii)   shared power to vote or to direct the vote
                         5,428,478
                 (iii)   sole power to dispose or to direct the disposition of
                         0
                  (iv)   shared power to dispose or to direct the disposition of
                         5,428,478


ITEM 5.   OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.
          IF THIS STATEMENT IS BEING FILED TO REPORT THE FACT THAT AS OF THE
          DATE HEREOF THE REPORTING PERSON HAS CEASED TO BE THE BENEFICIAL OWNER
          OF MORE THAN 5% OF THE CLASS OF SECURITIES CHECK THE FOLLOWING [ ].

ITEM 6.   OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.

     CLSP, CLSP II, CLSP/SBS I, and CLSP/SBS II are each private investment
partnerships, the sole general partner of which is Cooper, LLC. As the sole
general partner of CLSP, CLSP II, CLSP/SBS I, and CLSP/SBS II, Cooper, LLC has
the power to vote and dispose of the Securities owned by each of CLSP, CLSP II,
CLSP/SBS I, and CLSP/SBS II and, accordingly, may be deemed the "beneficial
owner" of such Securities. The managing member of Cooper, LLC is Casdin, LLC of
which Jeffrey Casdin is the managing member

     Pursuant to an investment advisory contract, Cooper Hill Partners, L.P.
currently has the power to vote and dispose of the Securities held for the
account of CLSP Overseas and, accordingly, may be deemed the "beneficial owner"
of such Securities. Mr. Casdin is the managing member of Casdin, LLC, the
general partner of Cooper Hill Partners, L.P.

ITEM      7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED
          THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY.




Schedule 13G/A                                                    PAGE 15 OF 16

                  Not applicable.

ITEM 8.   IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.
          Not applicable.

ITEM 9.   NOTICE OF DISSOLUTION OF GROUP.
          Not applicable.




Schedule 13G/A                                                  PAGE 16 OF 16

ITEM 10.  CERTIFICATION.  (if filing pursuant to Rule 13d-1(c))

     Each of the Reporting Persons and CLSP Overseas, Ltd. hereby make the
following certification:

          By signing below each Reporting Person certifies that, to the best of
its knowledge and belief, the securities referred to above were not acquired and
are not held for the purpose of or with the effect of changing or influencing
the control of the issuer of the Securities and were not acquired and not held
in connection with or as a participant in any transaction having that purpose or
effect.


                                   SIGNATURES

      After reasonable inquiry and to the best of our knowledge and belief, the
undersigned certify that the information set forth in this statement is true,
complete and correct.

DATED:  February 17, 2004           /s/ Jeffrey Casdin,
                                    JEFFREY CASDIN, individually,and
                                    as managing member of Cooper Hill
                                    Partners, LLC, and on behalf of CLSP,
                                    L.P., CLSP II, L.P., CLSP/SBS I, L.P.,
                                    and CLSP/SBS II, L.P. and as the sole
                                    member of Casdin Capital, L.L.C., the
                                    general partner of Cooper Hill Partners,
                                    L.P.